On the other hand, field observations of the relative positions of points can be plotted and oriented to produce a map. Thus, orientation of any line or position - latitude, and longitude - of point can be determined.

In the past, positioning, tracking, mapping and navigation depend largely on astronomical observations that consist of measuring position of the sun or particular stars.

this method was successfully applied to forced degradation studies and can be adopted for routine estimation of fulvestrant in quality control laboratories. Conclusions: The low % RSD values (= 2) indicated that the method was precise and accurate. Both intraday and inter day accuracy and precision data showed good reproducibility. The method was linear over the concentration range of 0.08to 2ìg/ml with coefficient of correlation (r2) 0.99997. The percentage recovery of fulvestrant was found to be 99.1% - 100.75% which are within the limit. The retention time of fulvestrant was found to be 13.6 min. Results & Discussions: The chromatograms showed good peak shapes and no interference of solvent peaks.

Method: Fulvestrant was measured using a validated HPLC method with UV detector at 225nm chromatographic peaks were separated on Phenomix, C18 column (250 mm x 4.6 mm x3.5µ) using 50% aetonitrile in channel A and acetonitlile in channel B as mobile phase with gradient elution at a flow rate of 1 ml/min. Aim: The present work is aimed to develop a simple, rapid, selective, sensitive and validated HPLC method for the determination of fulvestrant in bulk drug.

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